Which form of cellular adaptation occurs because of decreased work demands on the cell? Explain your answer. A. Hypertrophy B. Hyperplasia C. Atrophy D. Metaplasia Reply to this post with 250 words, no plagiarism please. The answer is C, Atrophy. Atrophy is a kind of celular adaptation mechanism in which the celular size decrease due to a reduction in the consumption of all kind of nutrients, a reduction on the celular demand/metabolic requirements for several etiologic factors. For instance, a marked decrease of total muscular mass, can be observed on clients with long periods of illness recovery due to lack of organ (muscles) use.